Female sexual dysfunction is age-related, progressive and highly prevalent affecting 30-54 percent of women. According to National Health and Social Life Survey of 1,800 women, 45 percent experienced sexual dysfunction. U.S. population survey data reveal that over 9 million American women ages 48-75 find fault of little vaginal lubrication, pain and discomfort while intercourse, decreased arousal, and difficulty achieving orgasm. Female sexual dysfunction is undoubtedly an important women's health issue that affects the quality of life of many women.

Till now there has been little research has been focused on female sexual function. Due to that reason, knowledge and understanding of the composition and physiology of the female sexual response is quite limited. Based on the understanding of the physiology of the male erectile response, recent advances in modern technology, and recent interest in Women's Health issues, the study of female dysfunction is gradually evolving.

According to Researchers "it's not just men who undergo changes in their sex-organ blood-flow patterns. Women also tolerate nearly identical changes as well". To be sure about this thing, blood engorgement of the vaginal tissues may be harder to see than the changes in a penis as it becomes erect, but more and more doctors now believe that a healthy sexual response in women is as dependent on a well functioning vasculature as it is in men. Vaginal lubrication, for instance, is just one illustration of a process that's highly reliant on ample blood flow in the urogenital arteries. Nitric oxide will definitely enhance blood-flow patterns to the female sex organ.

Nitric oxide(Nitric oxide (NO) is a free radical gas that is a powerful regulator of circulation (it is an endogenous vasodilator).) and glutamate amalgamation control the sexual function of females, including enhanced lubrication and sensitivity, as well as sexual response. It also promotes the release of the neurotransmitter Glutamate, which stimulates the release of the pro-sexual hormone oxytocin.